
                                SEQUENCE LISTING

<110> Liu, Chuanju

<120> PEPTIDES TARGETTING TNF FAMILY RECEPTORS
  AND ANTAGONIZING TNF ACTION, COMPOSITIONS, METHODS AND USES
  THEREOF
  

<130> 1049-1-124PCT

<140> UNASSIGNED          
<141> 2010-04-16  

<150> 61/212,971          
<151> 2009-04-17  

<160> 10

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 593
<212> PRT
<213> Homo sapiens

<400> 1
Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala
 1               5                  10                  15      
Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu
            20                  25                  30          
Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys
        35                  40                  45              
Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp
    50                  55                  60                  
Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr
65                  70                  75                  80  
Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His
                85                  90                  95      
His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys
            100                 105                 110         
Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp
        115                 120                 125             
Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp
    130                 135                 140                 
Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp
145                 150                 155                 160 
Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr
                165                 170                 175     
Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro
            180                 185                 190         
Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys
        195                 200                 205             
Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu
    210                 215                 220                 
Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys
225                 230                 235                 240 
Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile
                245                 250                 255     
Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr
            260                 265                 270         
Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val
        275                 280                 285             
Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp
    290                 295                 300                 
Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His
305                 310                 315                 320 
Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu
                325                 330                 335     
Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu
            340                 345                 350         
Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn
        355                 360                 365             
Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly
    370                 375                 380                 
Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His
385                 390                 395                 400 
Gln His Cys Cys Pro Gln Arg Tyr Thr Cys Val Ala Glu Gly Gln Cys
                405                 410                 415     
Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg
            420                 425                 430         
Arg Gly Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr
        435                 440                 445             
Ser Cys Pro Val Gly Gly Thr Cys Cys Pro Ser Gln Gly Gly Ser Trp
    450                 455                 460                 
Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His
465                 470                 475                 480 
Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu
                485                 490                 495     
Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro
            500                 505                 510         
His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His
        515                 520                 525             
Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys
    530                 535                 540                 
Pro Tyr Ala Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro
545                 550                 555                 560 
Ala Gly Phe Arg Cys Ala Arg Arg Gly Thr Lys Cys Leu Arg Arg Glu
                565                 570                 575     
Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu
            580                 585                 590         
Leu
    


<210> 2
<211> 158
<212> PRT
<213> Artificial Sequence

<220> 
<223> atsttrin peptide derived from human GEP

<400> 2
Pro Gln Ala Ser Cys Cys Glu Asp Arg Val His Cys Cys Pro His Gly
 1               5                  10                  15      
Ala Phe Cys Asp Leu Val His Thr Arg Cys Ile Thr Pro Thr Gly Thr
            20                  25                  30          
His Pro Leu Ala Lys Lys Leu Pro Ala Gln Arg Thr Asn Arg Ala Val
        35                  40                  45              
Ala Leu Ser Ser Ser Ala Ser Ser Lys Glu Asn Ala Thr Thr Asp Leu
    50                  55                  60                  
Leu Thr Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met
65                  70                  75                  80  
Glu Val Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly
                85                  90                  95      
Ala Trp Pro Trp Cys Glu Gln Gly Pro His Gln Val Pro Trp Met Glu
            100                 105                 110         
Lys Ala Pro Ala His Leu Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg
        115                 120                 125             
Asp Val Pro Cys Asp Asn Val Ser Ser Cys Pro Ser Ser Asp Thr Cys
    130                 135                 140                 
Cys Gln Leu Thr Ser Gly Glu Trp Gly Cys Cys Pro Ile Pro
145                 150                 155             


<210> 3
<211> 63
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide derived from human GEP

<400> 3
Ile Gln Cys Pro Asp Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys
 1               5                  10                  15      
Cys Val Met Val Asp Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala
            20                  25                  30          
Ser Cys Cys Glu Asp Arg Val His Cys Cys Pro His Gly Ala Phe Cys
        35                  40                  45              
Asp Leu Val His Thr Arg Cys Ile Thr Pro Thr Gly Thr His Pro
    50                  55                  60              


<210> 4
<211> 75
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide derived from human GEP

<400> 4
Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr Lys Leu Pro Ala His
 1               5                  10                  15      
Thr Val Gly Asp Val Lys Cys Asp Met Glu Val Ser Cys Pro Asp Gly
            20                  25                  30          
Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp Gly Cys Cys Pro Phe
        35                  40                  45              
Thr Gln Ala Val Cys Cys Glu Asp His Ile His Cys Cys Pro Ala Gly
    50                  55                  60                  
Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu
65                  70                  75  


<210> 5
<211> 81
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide derived from human GEP

<400> 5
Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu
 1               5                  10                  15      
Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn
            20                  25                  30          
Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly
        35                  40                  45              
Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His
    50                  55                  60                  
Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys
65                  70                  75                  80  
Gln
    


<210> 6
<211> 98
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide derived from human GEP

<400> 6
Pro Gln Ala Ser Cys Cys Glu Asp Arg Val His Cys Cys Pro His Gly
 1               5                  10                  15      
Ala Phe Cys Asp Leu Val His Thr Arg Cys Ile Thr Pro Thr Gly Thr
            20                  25                  30          
His Pro Leu Ala Lys Lys Leu Pro Ala Gln Arg Thr Asn Arg Ala Val
        35                  40                  45              
Ala Leu Ser Ser Ser Ala Ser Ser Lys Glu Asn Ala Thr Thr Asp Leu
    50                  55                  60                  
Leu Thr Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met
65                  70                  75                  80  
Glu Val Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly
                85                  90                  95      
Ala Trp
        


<210> 7
<211> 103
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide derived from human GEP

<400> 7
Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr Lys Leu Pro Ala His
 1               5                  10                  15      
Thr Val Gly Asp Val Lys Cys Asp Met Glu Val Ser Cys Pro Asp Gly
            20                  25                  30          
Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp Pro Trp Cys Glu Gln
        35                  40                  45              
Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu Ser
    50                  55                  60                  
Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn Val
65                  70                  75                  80  
Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly Glu
                85                  90                  95      
Trp Gly Cys Cys Pro Ile Pro
            100             


<210> 8
<211> 588
<212> PRT
<213> Mus musculus

<400> 8
Met Trp Ile Leu Val Ser Trp Leu Ala Leu Val Ala Arg Leu Val Ala
 1               5                  10                  15      
Gly Thr Gln Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu
            20                  25                  30          
Asp Gln Gly Gly Ala Asn Tyr Ser Cys Cys Asn Pro Leu Leu Asp Thr
        35                  40                  45              
Trp Pro Ile Ile Thr Ser Arg Arg Leu Asp Gly Ser Cys Gln Ile Arg
    50                  55                  60                  
Asp His Cys Pro Asp Gly Tyr Ser Cys Leu Leu Thr Val Ser Gly Thr
65                  70                  75                  80  
Ser Ser Cys Cys Pro Phe Ser Glu Gly Val Ser Cys Asp Asp Gly Gln
                85                  90                  95      
His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Lys Ser Cys
            100                 105                 110         
Ser Gln Ile Ser Asp Ser Leu Leu Gly Ala Val Gln Cys Pro Gly Ser
        115                 120                 125             
Gln Phe Glu Cys Pro Asp Ser Ala Thr Cys Cys Ile Met Ile Asp Gly
    130                 135                 140                 
Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp Arg
145                 150                 155                 160 
Val His Cys Cys Pro His Gly Ala Ser Cys Asp Leu Val His Thr Arg
                165                 170                 175     
Cys Ile Ser Pro Thr Gly Thr His Pro Leu Leu Lys Lys Phe Pro Ala
            180                 185                 190         
Gln Arg Thr Asn Arg Ala Val Ala Ser Phe Ser Val Val Cys Pro Asp
        195                 200                 205             
Ala Lys Thr Gln Cys Pro Asp Asp Ser Thr Cys Cys Glu Leu Pro Thr
    210                 215                 220                 
Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Ile Cys Cys Ser Asp
225                 230                 235                 240 
His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile Gln Ser
                245                 250                 255     
Lys Cys Ile Ser Lys Asp Tyr Thr Thr Asp Leu Met Thr Lys Leu Pro
            260                 265                 270         
Gly Tyr Pro Val Asn Glu Val Lys Cys Asp Leu Glu Val Ser Cys Pro
        275                 280                 285             
Asp Gly Tyr Thr Cys Cys Arg Leu Asn Thr Gly Ala Trp Gly Cys Cys
    290                 295                 300                 
Pro Phe Thr Lys Ala Val Cys Cys Glu Asp His Ile His Cys Cys Pro
305                 310                 315                 320 
Ala Gly Phe Gln Cys His Thr Glu Thr Gly Thr Cys Glu Leu Gly Val
                325                 330                 335     
Leu Gln Val Pro Trp Met Lys Lys Val Thr Ala Ser Leu Ser Leu Pro
            340                 345                 350         
Asp Pro Gln Ile Leu Lys Asn Asp Val Pro Cys Asp Asp Phe Ser Ser
        355                 360                 365             
Cys Pro Ser Asn Asn Thr Cys Cys Arg Leu Ser Ser Gly Asp Trp Gly
    370                 375                 380                 
Cys Cys Pro Met Pro Glu Ala Val Cys Cys Leu Asp His Gln His Cys
385                 390                 395                 400 
Cys Pro Gln Gly Phe Lys Cys Met Asp Glu Gly Tyr Cys Gln Lys Gly
                405                 410                 415     
Asp Arg Met Val Ala Gly Leu Glu Lys Met Pro Val Arg Gln Thr Thr
            420                 425                 430         
Leu Leu Gln His Gly Asp Ile Gly Cys Asp Gln His Thr Ser Cys Pro
        435                 440                 445             
Val Gly Gln Thr Cys Cys Pro Ser Leu Lys Gly Ser Trp Ala Cys Cys
    450                 455                 460                 
Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His Cys Cys Pro
465                 470                 475                 480 
Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Thr Cys Glu Lys Asp Ala
                485                 490                 495     
Gly Ser Val Gln Pro Ser Met Asp Leu Thr Phe Gly Ser Lys Val Gly
            500                 505                 510         
Asn Val Glu Cys Gly Ala Gly His Phe Cys His Asp Asn Gln Ser Cys
        515                 520                 525             
Cys Lys Asp Ser Gln Gly Gly Trp Ala Cys Cys Pro Tyr Val Lys Gly
    530                 535                 540                 
Val Cys Cys Arg Asp Gly Arg His Cys Cys Pro Ile Gly Phe His Cys
545                 550                 555                 560 
Ser Ala Lys Gly Thr Lys Cys Leu Arg Lys Lys Thr Pro Arg Trp Asp
                565                 570                 575     
Ile Leu Leu Arg Asp Pro Ala Pro Arg Pro Leu Leu
            580                 585             


<210> 9
<211> 53
<212> PRT
<213> Artificial Sequence

<220> 
<223> consensus

<221> VARIANT        
<222> (2)...(6)
<223> Xaa can  be any amiino acid

<221> VARIANT        
<222> (7)...(7)
<223> Xaa can be any amino acid or none

<221> VARIANT        
<222> (9)...(13)
<223> Xaa can be any amino acid

<221> VARIANT        
<222> (16)...(23)
<223> Xaa can be any amino acid

<221> VARIANT        
<222> (26)...(31)
<223> Xaa can be any amino acid

<221> VARIANT        
<222> (34)...(34)
<223> Xaa can be any amino acid

<221> VARIANT        
<222> (36)...(37)
<223> Xaa can be any amino acid

<221> VARIANT        
<222> (42)...(45)
<223> Xaa can be any amino acid

<221> VARIANT        
<222> (47)...(51)
<223> Xaa can be any amino acid

<221> VARIANT        
<222> (52)...(52)
<223> Xaa can be any amino acid or none

<400> 9
Cys Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Cys Xaa
 1               5                  10                  15      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Cys Xaa Xaa Xaa Xaa Xaa Xaa Cys
            20                  25                  30          
Cys Xaa Asp Xaa Xaa His Cys Cys Pro Xaa Xaa Xaa Xaa Cys Xaa Xaa
        35                  40                  45              
Xaa Xaa Xaa Xaa Cys
    50              


<210> 10
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> consensus

<221> VARIANT        
<222> (3)...(3)
<223> Xaa can be any amino acid

<221> VARIANT        
<222> (5)...(6)
<223> Xaa can be any amino acid

<400> 10
Cys Cys Xaa Asp Xaa Xaa His Cys Cys Pro
 1               5                  10  

